Prkci^tm1.1Rfar
Targeted Allele Detail

Summary

• Symbol: Prkci^tm1.1Rfar
• Name: protein kinase C, iota; targeted mutation 1.1, Robert V Farese Sr
• MGI ID: MGI:5520927
• Synonyms: PKCiota/lambda delta
• Gene: Prkci Location: Chr3:31049893-31106889 bp, + strand Genetic Position: Chr3, 14.65 cM
• Alliance: Prkci^tm1.1Rfar page

Abnormal development of Prkci^tm1.1Rfar/Prkci^tm1.1Rfar embryos

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:202124
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: The exon containing nucleotides 110-233 (exon 2) was flanked by loxP sites. A neomycin resistance cassette was inserted downstream of the exon. Cre-mediated recombination removed exon 2 and the neomycin resistance cassette. (J:202124)

Generation of the Prkci^tm1.1Rfar allele

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkci Mutation: 69 strains or lines available

References

• Original: J:202124 Seidl S, et al., Phenotypical analysis of atypical PKCs in vivo function display a compensatory system at mouse embryonic day 7.5. PLoS One. 2013;8(5):e62756
• All: 1 reference(s)