Gal3st1^tm1.1Hjg
Targeted Allele Detail

Summary

• Symbol: Gal3st1^tm1.1Hjg
• Name: galactose-3-O-sulfotransferase 1; targeted mutation 1.1, Herman-Josef Grone
• MGI ID: MGI:5520956
• Synonyms: Cst^fl
• Gene: Gal3st1 Location: Chr11:3933636-3949326 bp, + strand Genetic Position: Chr11, 2.81 cM, cytoband A1
• Alliance: Gal3st1^tm1.1Hjg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197393
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site followed by an FRT flanked neomycin resistance cassette was inserted 5' of the second coding exon and a second loxP site was inserted downstream of this exon. Flp recombinase expression in properly targeted mice excised the selection cassette leaving the second coding exon flanked by loxP sites. (J:197393)

Generation of the Gal3st1^tm1.1Hjg allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gal3st1 Mutation: 22 strains or lines available

References

• Original: J:197393 Stettner P, et al., Sulfatides are required for renal adaptation to chronic metabolic acidosis. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9998-10003
• All: 3 reference(s)