Lrig1^{tm1(cre/ERT2)Kjen}
Targeted Allele Detail

Summary

• Symbol: Lrig1^{tm1(cre/ERT2)Kjen}
• Name: leucine-rich repeats and immunoglobulin-like domains 1; targeted mutation 1, Kim B Jensen
• MGI ID: MGI:5520983
• Synonyms: Lrig1-EGFP, Lrig1-EGFP-ires-CreERT2, Lrig1::eGFP-IRES-CreER^T2
• Gene: Lrig1 Location: Chr6:94581510-94677139 bp, - strand Genetic Position: Chr6, 43.15 cM
• Alliance: Lrig1^{tm1(cre/ERT2)Kjen} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:202041
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Lrig1^{tm1(cre/ERT2)Kjen} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Lrig1 (MGI:107935)

• Mutation details: An EGFP-IRES-cre/ERT2 cassette was knocked into the translational start site in exon 1 of the endogenous Lrig1 gene in ES cells using homologous recombination. (J:202041)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Lrig1 (mouse) Summary of all recombinase alleles driven by Lrig1. Comparative matrix view of recombinase activities Alliance mouse Lrig1 gene page

Expression

In Mice Carrying this Mutation:

29 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrig1 Mutation: 50 strains or lines available

References

• Original: J:202041 Page ME, et al., The epidermis comprises autonomous compartments maintained by distinct stem cell populations. Cell Stem Cell. 2013 Oct 3;13(4):471-82
• All: 14 reference(s)