Cd19^tm1.1Oao
Targeted Allele Detail

Summary

• Symbol: Cd19^tm1.1Oao
• Name: CD19 antigen; targeted mutation 1.1, Owen A O'Connor
• MGI ID: MGI:5521189
• Synonyms: CD19CherryLuciferase
• Gene: Cd19 Location: Chr7:126007622-126014061 bp, - strand Genetic Position: Chr7, 69.01 cM, cytoband F3-F4
• Alliance: Cd19^tm1.1Oao page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:202574
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The construct targeted to exon 2 contains a mCherry and luciferase fusion, polyadenylation sequence and floxed neomycin resistance cassette. Cre-mediated recombination removed the neomycin resistance cassette. (J:202574)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cd19 Mutation: 60 strains or lines available

References

• Original: J:202574 Scotto L, et al., Development and characterization of a novel CD19CherryLuciferase (CD19CL) transgenic mouse for the preclinical study of B-cell lymphomas. Clin Cancer Res. 2012 Jul 15;18(14):3803-11
• All: 2 reference(s)