Psmb11^{tm1.1(icre)Yout}
Targeted Allele Detail

Summary

• Symbol: Psmb11^{tm1.1(icre)Yout}
• Name: proteasome (prosome, macropain) subunit, beta type, 11; targeted mutation 1.1, Yousuke Takahama
• MGI ID: MGI:5521209
• Synonyms: beta5t-Cre
• Gene: Psmb11 Location: Chr14:54862767-54867013 bp, + strand Genetic Position: Chr14, 27.87 cM
• Alliance: Psmb11^{tm1.1(icre)Yout} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197387
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129 x C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout, Recombinase)
• Mutations: Insertion, Intragenic deletion
• Psmb11^{tm1.1(icre)Yout} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Psmb11 (MGI:1921152)

• Mutation details: A codon improved cre cDNA and FRT flanked PGKK-neo cassette in reverse orientation were inserted in place of most of the sole exon. The PGK- neo was subsequently removed from properly targeted mice by flp recombinase expression. (J:197387)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Psmb11 (mouse) Summary of all recombinase alleles driven by Psmb11. Comparative matrix view of recombinase activities Alliance mouse Psmb11 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Psmb11 Mutation: 11 strains or lines available

References

• Original: J:197387 Ohigashi I, et al., Aire-expressing thymic medullary epithelial cells originate from beta5t-expressing progenitor cells. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9885-90
• All: 8 reference(s)