Slc9b2^tm1.1Dgfu
Targeted Allele Detail

Summary

• Symbol: Slc9b2^tm1.1Dgfu
• Name: solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2; targeted mutation 1.1, Daniel G Fuster
• MGI ID: MGI:5521370
• Synonyms: NHA2 KO
• Gene: Slc9b2 Location: Chr3:135013083-135048606 bp, + strand Genetic Position: Chr3, 62.55 cM
• Alliance: Slc9b2^tm1.1Dgfu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197386
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo/Tk selection cassette was inserted upstream of exon 7 and a third loxP site was inserted downstream. The selection cassette and exon 7 were then excised from properly targeted ES cells by transient cre expression. Protein and mRNA were not detected in islets of knockout mice. (J:197386)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc9b2 Mutation: 45 strains or lines available

References

• Original: J:197386 Deisl C, et al., Sodium/hydrogen exchanger NHA2 is critical for insulin secretion in beta-cells. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):10004-9
• All: 3 reference(s)