Egln1^tm2.1Fsl
Targeted Allele Detail

Summary

• Symbol: Egln1^tm2.1Fsl
• Name: egl-9 family hypoxia-inducible factor 1; targeted mutation 2.1, Frank Lee
• MGI ID: MGI:5521468
• Synonyms: Phd2^f
• Gene: Egln1 Location: Chr8:125635326-125676063 bp, - strand Genetic Position: Chr8, 72.86 cM
• Alliance: Egln1^tm2.1Fsl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:202737
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert loxP sites on either side of exon 2 followed by an FRT-flanked neomycin selection cassette. The neomycin resistance cassette was removed by Flpe-mediated recombination using mice carrying the Tg(CAG-Flpe)2Arte allele. (J:202737)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Egln1 Mutation: 22 strains or lines available

References

• Original: J:202737 Arsenault PR, et al., A Knock-in Mouse Model of Human PHD2 Gene-associated Erythrocytosis Establishes a Haploinsufficiency Mechanism. J Biol Chem. 2013 Nov 22;288(47):33571-84
• All: 2 reference(s)