About   Help   FAQ
Mirc19tm1.2Arte
Targeted Allele Detail
Summary
Symbol: Mirc19tm1.2Arte
Name: microRNA cluster 19, including Mir212 through Mir132; targeted mutation 1.2, TaconicArtemis
MGI ID: MGI:5521495
Synonyms: miR-132/212-, Mir212/Mir132tm1.2Arte
Gene: Mirc19  Location: Chr11:75064214-75064573 bp  Genetic Position: Chr11, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:200865
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of Mir212. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of Mir132. Flp-mediated recombination removed the neomycin resistance cassette and left the two microRNAs floxed. Cre-mediated recombination removed the two microRNAs. (J:200865)
Generation of the Mirc19tm1.1Arte and Mirc19tm1.2Arte alleles
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mirc19 Mutation:  0 strains or lines available
References
Original:  J:200865 Remenyi J, et al., miR-132/212 knockout mice reveal roles for these miRNAs in regulating cortical synaptic transmission and plasticity. PLoS One. 2013;8(4):e62509
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/22/2024
MGI 6.24
The Jackson Laboratory