Mirc19^tm1.2Arte
Targeted Allele Detail

Summary

• Symbol: Mirc19^tm1.2Arte
• Name: microRNA cluster 19, including Mir212 through Mir132; targeted mutation 1.2, TaconicArtemis
• MGI ID: MGI:5521495
• Synonyms: miR-132/212^-, Mir212/Mir132^tm1.2Arte
• Gene: Mirc19 Location: Chr11:75064214-75064573 bp Genetic Position: Chr11, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:200865
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of Mir212. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of Mir132. Flp-mediated recombination removed the neomycin resistance cassette and left the two microRNAs floxed. Cre-mediated recombination removed the two microRNAs. (J:200865)

Generation of the Mirc19^tm1.1Arte and Mirc19^tm1.2Arte alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mirc19 Mutation: 0 strains or lines available

References

• Original: J:200865 Remenyi J, et al., miR-132/212 knockout mice reveal roles for these miRNAs in regulating cortical synaptic transmission and plasticity. PLoS One. 2013;8(4):e62509
• All: 5 reference(s)