Nr1h4^tm1.1Mbj
Targeted Allele Detail

Summary

• Symbol: Nr1h4^tm1.1Mbj
• Name: nuclear receptor subfamily 1, group H, member 4; targeted mutation 1.1, Mikael Bjursell
• MGI ID: MGI:5521510
• Gene: Nr1h4 Location: Chr10:89290096-89369447 bp, - strand Genetic Position: Chr10, 44.98 cM
• Alliance: Nr1h4^tm1.1Mbj page

Nr1h4^tm1.1Mbj/Nr1h4^tm1.1Mbj livers show perisinusoidal/sinusoidal foam cells, lobular inflammation and ballooning degeneration

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:200842
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 9. A floxed neomycin resistance cassette was inserted dowsntream of exon 9. Cre-mediated recombination removed exon 9 and the neomycin resistance cassette. RT-PCR confirmed the absence of transcript expression in the liver. (J:200842)

Generation of the Nr1h4^tm1.1Mbj allele

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr1h4 Mutation: 43 strains or lines available

References

• Original: J:200842 Bjursell M, et al., Ageing Fxr deficient mice develop increased energy expenditure, improved glucose control and liver damage resembling NASH. PLoS One. 2013;8(5):e64721
• All: 1 reference(s)