Sdhb^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Sdhb^tm1.1Ics
• Name: succinate dehydrogenase complex, subunit B, iron sulfur (Ip); targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:5521531
• Synonyms: Sdhb^lox
• Gene: Sdhb Location: Chr4:140688582-140706509 bp, + strand Genetic Position: Chr4, 73.24 cM, cytoband E1
• Alliance: Sdhb^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199113
• Parent Cell Line: P1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neomycin resistance cassette and left exon 2 floxed. (J:199113)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sdhb Mutation: 29 strains or lines available

References

• Original: J:199113 Letouze E, et al., SDH mutations establish a hypermethylator phenotype in paraganglioma. Cancer Cell. 2013 Jun 10;23(6):739-52
• All: 2 reference(s)