Vapb^tm1.2Ics
Targeted Allele Detail

Summary

• Symbol: Vapb^tm1.2Ics
• Name: vesicle-associated membrane protein, associated protein B and C; targeted mutation 1.2, Mouse Clinical Institute
• MGI ID: MGI:5521564
• Synonyms: Vapb^deltaexon3, Vapb^tm1.2Ldps
• Gene: Vapb Location: Chr2:173579378-173626132 bp, + strand Genetic Position: Chr2, 97.37 cM, cytoband H3
• Alliance: Vapb^tm1.2Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198145
• Parent Cell Line: P1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed a floxed neomycin resistance cassette. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. Western blot anlaysis confirmed the absence of protein expression in the cerebral cortex. (J:198145)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Vapb Mutation: 30 strains or lines available

References

• Original: J:198145 Kabashi E, et al., Investigating the contribution of VAPB/ALS8 loss of function in amyotrophic lateral sclerosis. Hum Mol Genet. 2013 Jun 15;22(12):2350-60
• All: 3 reference(s)