Tgm2^tm2.1Rmgr
Targeted Allele Detail

Summary

• Symbol: Tgm2^tm2.1Rmgr
• Name: transglutaminase 2, C polypeptide; targeted mutation 2.1, Robert M Graham
• MGI ID: MGI:5521582
• Synonyms: TG2^R579A, TG2^R579A deltaneo
• Gene: Tgm2 Location: Chr2:157958325-157988312 bp, - strand Genetic Position: Chr2, 78.72 cM
• Alliance: Tgm2^tm2.1Rmgr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:200838
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Constitutively active)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 11 was replaced with a modified exon 11 in which nucleotide substitutions (AGA to GCC) result in the amino acid substitution of alanine for arginine at position 579 (R579A). This mutation results in a constitutively active protein. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted downstream of the modified exon 11. (J:200838)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tgm2 Mutation: 49 strains or lines available

References

• Original: J:200838 Iismaa SE, et al., Glucose homeostasis in mice is transglutaminase 2 independent. PLoS One. 2013;8(5):e63346
• All: 1 reference(s)