Tg(KRT14-FLT4/IGHG1)#Ali
Transgene Detail

Summary

• Symbol: Tg(KRT14-FLT4/IGHG1)#Ali
• Name: transgene insertion, Kari Alitalo
• MGI ID: MGI:5522572
• Synonyms: K14-FLT4, K14-VEGFR-3-Ig
• Transgene: Tg(KRT14-FLT4/IGHG1)#Ali Location: unknown
• Alliance: Tg(KRT14-FLT4/IGHG1)#Ali page

Increase in mononuclear phagocyte system cells in Tg(KRT14-FLT4/IGHG1)#Ali/0 mice fed a low-salt diet

Show the 1 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(KRT14-FLT4/IGHG1)#Ali expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  FLT4 (2324)

  Flt4	(MGI:95561)

  Transgene codes for a fusion protein of FLT4 and IGHG1.

  human

  IGHG1 (3500)

  Ighg	(MGI:2144967)
  Ighg1	(MGI:96446)
  Ighg2a	(MGI:96443)
  Ighg2b	(MGI:96445)
  Ighg2c	(MGI:2686979)
  Ighg3	(MGI:2144790)

  Transgene codes for a fusion protein of FLT4 and IGHG1.

• Mutation details: The human promoter drives basal epidermal cell-specific expression of the human cDNA corresponding to Ig homology domains 1 through 3 fused with a human IGHG1 Fc tail to generate a soluble protein. Three lines were generated (27, 51 and 95). The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:134553)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

The transgene was inserted into FVB/N or DBA x BALB/c oocytes (J:134553).

References

• Original: J:134553 Makinen T, et al., Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3. Nat Med. 2001 Feb;7(2):199-205
• All: 19 reference(s)