Tigar^tm1.1Khv
Targeted Allele Detail

Summary

• Symbol: Tigar^tm1.1Khv
• Name: Trp53 induced glycolysis regulatory phosphatase; targeted mutation 1.1, Karen H Vousden
• MGI ID: MGI:5522697
• Synonyms: TIGAR^fl
• Gene: Tigar Location: Chr6:127062079-127086520 bp, - strand Genetic Position: Chr6, 61.92 cM
• Alliance: Tigar^tm1.1Khv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198650
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the neomycin resistance cassette and left exon 3 floxed. (J:198650)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tigar^tm1.1Khv

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tigar Mutation: 58 strains or lines available

References

• Original: J:198650 Cheung EC, et al., TIGAR Is Required for Efficient Intestinal Regeneration and Tumorigenesis. Dev Cell. 2013 Jun 10;25(5):463-77
• All: 3 reference(s)