Trpm2^tm1Lhj
Targeted Allele Detail

Summary

• Symbol: Trpm2^tm1Lhj
• Name: transient receptor potential cation channel, subfamily M, member 2; targeted mutation 1, Lin-Hua Jiang
• MGI ID: MGI:5522800
• Gene: Trpm2 Location: Chr10:77743556-77805746 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Trpm2^tm1Lhj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:202791
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exons 17 and 18. This allele produces a protein lacking the Leu843 to Met931 segment that does not produce a functional channel. (J:202791)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trpm2 Mutation: 112 strains or lines available

References

• Original: J:202791 Zou J, et al., A differential role of macrophage TRPM2 channels in Ca(2)(+) signaling and cell death in early responses to H(2)O(2). Am J Physiol Cell Physiol. 2013 Jul 1;305(1):C61-9
• All: 11 reference(s)