Abhd5^tm1.1Lqyu
Targeted Allele Detail

Summary

• Symbol: Abhd5^tm1.1Lqyu
• Name: abhydrolase domain containing 5; targeted mutation 1.1, Liqing Yu
• MGI ID: MGI:5523003
• Synonyms: CGI-58^f
• Gene: Abhd5 Location: Chr9:122180681-122210589 bp, + strand Genetic Position: Chr9, 73.03 cM, cytoband F4
• Alliance: Abhd5^tm1.1Lqyu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199570
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT- and loxP-flanked neomycin resistance cassette was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the neomycin resistance cassette and left exon 3 floxed. (J:199570)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Abhd5^tm1.1Lqyu

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abhd5 Mutation: 20 strains or lines available

References

• Original: J:199570 Guo F, et al., Deficiency of liver Comparative Gene Identification-58 causes steatohepatitis and fibrosis in mice. J Lipid Res. 2013 Aug;54(8):2109-20
• All: 7 reference(s)