Tg(Pcp2-ATXN3*69Q)bHirai
Transgene Detail

Summary

• Symbol: Tg(Pcp2-ATXN3*69Q)bHirai
• Name: transgene insertion b, Hirokazu Hirai
• MGI ID: MGI:5523235
• Synonyms: Tg(b)
• Transgene: Tg(Pcp2-ATXN3*69Q)bHirai Location: unknown
• Alliance: Tg(Pcp2-ATXN3*69Q)bHirai page

Transgene origin

• Strain of Origin: C57BL/6NCrSlc

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Pcp2-ATXN3*69Q)bHirai expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ATXN3 (4287)

  Atxn3

  (MGI:1099442)

• Mutation details: The cDNA encoding a N-terminal-truncated form (lacking 286 amino-acid residues) of human ATAXIN-3 with 69 glutamine repeats is driven by a Purkinje-cell specific L7 promoter (Pcp2). The ATG start codon in exon 2 of Pcp2 was mutated to inhibit the expression of exons 1-3. In addition an N-terminal hemagglutinin epitope was added. Three lines were generated, a, b, and c. (J:136101)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:136101 Torashima T, et al., Lentivector-mediated rescue from cerebellar ataxia in a mouse model of spinocerebellar ataxia. EMBO Rep. 2008 Apr;9(4):393-9
• All: 9 reference(s)