Gnl3^tm2.1Rylt
Targeted Allele Detail

Summary

• Symbol: Gnl3^tm2.1Rylt
• Name: guanine nucleotide binding protein nucleolar 3; targeted mutation 2.1, Robert Y L Tsai
• MGI ID: MGI:5523416
• Synonyms: NS^f
• Gene: Gnl3 Location: Chr14:30734390-30741088 bp, - strand Genetic Position: Chr14, 19.09 cM
• Alliance: Gnl3^tm2.1Rylt page

Severe brain defects in Gnl3^tm2.1Rylt/Gnl3^tm2.1Rylt Tg(Nes-cre)1Kln/0 embryos

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198698
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site and FRT flanked pgk-neo cassette were inserted 820 bp upstream of exon 1 and a second loxP site was inserted in the second intron. Flp mediated recombination removed the neo cassette. (J:198698)

Generation of the Gnl3^tm2.1Rylt and Gnl3^tm2.2Rylt alleles

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gnl3 Mutation: 56 strains or lines available

References

• Original: J:198698 Meng L, et al., Nucleostemin deletion reveals an essential mechanism that maintains the genomic stability of stem and progenitor cells. Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11415-20
• All: 2 reference(s)