Exo1^tm2Wed
Targeted Allele Detail

Summary

• Symbol: Exo1^tm2Wed
• Name: exonuclease 1; targeted mutation 2, Winfried Edelmann
• MGI ID: MGI:5523452
• Synonyms: Exo1^null
• Gene: Exo1 Location: Chr1:175708334-175738962 bp, + strand Genetic Position: Chr1, 81.9 cM
• Alliance: Exo1^tm2Wed page

Decreased testis weight in Exo1^tm2Wed/Exo1^tm2Wed males

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198719
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A hygromycin resistance cassette was inserted between exon 4 and 5, replacing the intron. Western blot analysis confirmed the absence of protein expression in the testis. (J:198719)

Gene-targeting strategy for the Exo1^tm2Wed allele

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Exo1 Mutation: 46 strains or lines available

References

• Original: J:198719 Schaetzlein S, et al., Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2470-9
• All: 2 reference(s)