Notch2^tm2(cre)Rko
Targeted Allele Detail

Summary

• Symbol: Notch2^tm2(cre)Rko
• Name: notch 2; targeted mutation 2, Raphael Kopan
• MGI ID: MGI:5523501
• Synonyms: N2::Cre, N2::Cre^LO
• Gene: Notch2 Location: Chr3:97920854-98057683 bp, + strand Genetic Position: Chr3, 42.42 cM
• Alliance: Notch2^tm2(cre)Rko page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198632
• Parent Cell Line: B6/BLU (ES Cell)
• Strain of Origin: C57BL/6NTac-Tg(HBB-lacZ)ALey/Ley

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Notch2^tm2(cre)Rko expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Notch2 (MGI:97364)

• The intracellular domain (ICD) of Notch2 was replaced with the cre recombinase sequence. (J:172930)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Notch2 (mouse) Summary of all recombinase alleles driven by Notch2. Alliance mouse Notch2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Notch2 Mutation: 99 strains or lines available

References

• Original: J:172930 Liu Z, et al., Rapid identification of homologous recombinants and determination of gene copy number with reference/query pyrosequencing (RQPS). Genome Res. 2009 Nov;19(11):2081-9
• All: 4 reference(s)