Hat1^tm1.1Mrpa
Targeted Allele Detail

Summary

• Symbol: Hat1^tm1.1Mrpa
• Name: histone aminotransferase 1; targeted mutation 1.1, Mark R Parthun
• MGI ID: MGI:5523519
• Synonyms: Hat1^-, Hat1^delta3
• Gene: Hat1 Location: Chr2:71219604-71271966 bp, + strand Genetic Position: Chr2, 42.38 cM
• Alliance: Hat1^tm1.1Mrpa page

Skeletal defects in Hat1^tm1.1Mrpa/Hat1^tm1.1Mrpa mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199077
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 3. A neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 3. Cre-mediated recombination removed exon 3 and the neomycin resistance cassette. The predicted product of this allele lacks the entire active site. Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts. (J:199077)

Generation of the Hat1^tm1Mrpa and Hat1^tm1.1Mrpa alleles

Expression

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	18 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hat1 Mutation: 43 strains or lines available

References

• Original: J:199077 Nagarajan P, et al., Histone acetyl transferase 1 is essential for mammalian development, genome stability, and the processing of newly synthesized histones H3 and H4. PLoS Genet. 2013 Jun;9(6):e1003518
• All: 2 reference(s)