Pkdcc^tm1.2Azun
Targeted Allele Detail

Summary

• Symbol: Pkdcc^tm1.2Azun
• Name: protein kinase domain containing, cytoplasmic; targeted mutation 1.2, Aimee Zuniga
• MGI ID: MGI:5523590
• Synonyms: Vlk^delta
• Gene: Pkdcc Location: Chr17:83522721-83532499 bp, + strand Genetic Position: Chr17, 52.25 cM
• Alliance: Pkdcc^tm1.2Azun page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199462
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, RMCE-ready)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP511site and loxP site were inserted upstream of exon 2 and an FRT flanked neo cassette, loxP site and loxP2722 site were inserted downstream of exon 3 via homologous recombination. Recombinase mediated recombination removed the neo cassette and exons 2 and 3, leaving behind loxP511, loxP, and loxP2722 sites. This allele is designed to permit recombination mediated cassette exchange. (J:199462)

Expression

In Mice Carrying this Mutation:	22 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pkdcc Mutation: 24 strains or lines available

References

• Original: J:199462 Probst S, et al., The hedgehog target Vlk genetically interacts with Gli3 to regulate chondrocyte differentiation during mouse long bone development. Differentiation. 2013 Apr-Jun;85(4-5):121-30
• All: 1 reference(s)