Ar^em1Liuy
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ar^em1Liuy
• Name: androgen receptor; endonuclease-mediated mutation 1, Yi-Xun Liu
• MGI ID: MGI:5523591
• Gene: Ar Location: ChrX:97192375-97366821 bp, + strand Genetic Position: ChrX, 42.82 cM
• Alliance: Ar^em1Liuy page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Zinc-finger nuclease technology generated a 4 bp deletion in exon 1 that results in a frameshift. Western blot analysis confirmed the absence of protein expresison in testes. (J:202050)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ar Mutation: 23 strains or lines available

References

• Original: J:202050 Li XX, et al., The Heat-Induced Reversible Change in the Blood-Testis Barrier (BTB) Is Regulated by the Androgen Receptor (AR) via the Partitioning-Defective Protein (Par) Polarity Complex in the Mouse. Biol Reprod. 2013 Jul;89(1):12
• All: 1 reference(s)