Isl1^Drsh
Chemically induced Allele Detail

Summary

• Symbol: Isl1^Drsh
• Name: ISL1 transcription factor, LIM/homeodomain; dearisch
• MGI ID: MGI:5523699
• Synonyms: Dea2
• Gene: Isl1 Location: Chr13:116434817-116446225 bp, - strand Genetic Position: Chr13, 64.87 cM, cytoband D2.3
• Alliance: Isl1^Drsh page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to C transition that results in the amino acid substitution of cysteine for a tyrosine at position 71 (Y71C). (J:202214)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Isl1 Mutation: 36 strains or lines available

Notes

Additional mutations found in this mouse line are listed in J:202214.

References

• Original: J:202214 Hilton JM, et al., Exome sequencing identifies a missense mutation in Isl1 associated with low penetrance otitis media in dearisch mice. Genome Biol. 2011;12(9):R90
• All: 2 reference(s)