Tg(Slc32a1-cre)65Kzy
Transgene Detail

Summary

• Symbol: Tg(Slc32a1-cre)65Kzy
• Name: transgene insertion 65, Kazuhiro Yamakawa
• MGI ID: MGI:5523786
• Synonyms: Tg65, VGAT-Cre, Viaat-Cre
• Transgene: Tg(Slc32a1-cre)65Kzy Location: unknown
• Alliance: Tg(Slc32a1-cre)65Kzy page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Slc32a1-cre)65Kzy expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Slc32a1 (MGI:1194488)

• Mutation details: Red/ET recombination was used to insert the sequences encoding cre recombinase, the SV40 poly(A) signal, and a kanamycin resistance gene at the ATG (translational initiation site) of the Slc32a1 (Vgat or Viaat) locus contained in RP23-392-P11 BAC clone derived from C57BL/6 mouse genomic DNA. The purified construct was injected into pronuclei of C57BL/6 oocytes. Transgenic line 65 was used in further analyses. (J:202863)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Slc32a1 (mouse) Summary of all recombinase alleles driven by Slc32a1. Comparative matrix view of recombinase activities Alliance mouse Slc32a1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:202863 Ogiwara I, et al., Nav1.1 haploinsufficiency in excitatory neurons ameliorates seizure-associated sudden death in a mouse model of Dravet syndrome. Hum Mol Genet. 2013 Dec 1;22(23):4784-804
• All: 15 reference(s)