Scn1a^tm2.2Kzy
Targeted Allele Detail

Summary

• Symbol: Scn1a^tm2.2Kzy
• Name: sodium channel, voltage-gated, type I, alpha; targeted mutation 2.2, Kazuhiro Yamakawa
• MGI ID: MGI:5523788
• Synonyms: Scn1a^d
• Gene: Scn1a Location: Chr2:66101125-66271181 bp, - strand Genetic Position: Chr2, 39.13 cM
• Alliance: Scn1a^tm2.2Kzy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:202863
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Floxed exon 7 was deleted in all tissues by crossing animals to EIIa-cre mice. (J:202863)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scn1a Mutation: 114 strains or lines available

References

• Original: J:202863 Ogiwara I, et al., Nav1.1 haploinsufficiency in excitatory neurons ameliorates seizure-associated sudden death in a mouse model of Dravet syndrome. Hum Mol Genet. 2013 Dec 1;22(23):4784-804
• All: 2 reference(s)