Mir429^m1Osb
Spontaneous Allele Detail

Summary

• Symbol: Mir429^m1Osb
• Name: microRNA 429; mutation 1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:5523793
• Synonyms: Mir429^T31COsb
• Gene: Mir429 Location: Chr4:156138362-156138444 bp, - strand Genetic Position: Chr4, 87.95 cM
• Alliance: Mir429^m1Osb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199159
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Single point mutation
• Mutation details: A point mutation (U-to-C in miRNA, A-to-G in forward genomic) mutated a residue critical for mature microRNA expression. Northern blot analysis confirmed the absence of microRNA expression. Expression of Mir200a is normal. (J:199159)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mir429 Mutation: 3 strains or lines available

Notes

This allele was generated in ES cells containing Mir200b^tm1.1Osb.

References

• Original: J:199159 Hasuwa H, et al., miR-200b and miR-429 function in mouse ovulation and are essential for female fertility. Science. 2013 Jul 5;341(6141):71-3
• All: 2 reference(s)