Tet1^tm1.1Gxu
Targeted Allele Detail

Summary

• Symbol: Tet1^tm1.1Gxu
• Name: tet methylcytosine dioxygenase 1; targeted mutation 1.1, Guo-Liang Xu
• MGI ID: MGI:5523869
• Gene: Tet1 Location: Chr10:62640349-62723242 bp, - strand Genetic Position: Chr10, 32.48 cM
• Alliance: Tet1^tm1.1Gxu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201001
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 11. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 13. Cre-mediated recombination removed exons 11 and through 13 (encoding the critical catalytic domain in dioxygenases) and the neomycin resistance cassette. RT-PCR confirmed the absence of transcript expression in the cortex, hippocampus and cerebellum. (J:201001)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tet1 Mutation: 143 strains or lines available

References

• Original: J:201001 Zhang RR, et al., Tet1 regulates adult hippocampal neurogenesis and cognition. Cell Stem Cell. 2013 Aug 1;13(2):237-45
• All: 8 reference(s)