Unc13a^tm4.1Bros
Targeted Allele Detail

Summary

• Symbol: Unc13a^tm4.1Bros
• Name: unc-13 homolog A; targeted mutation 4.1, Nils Brose
• MGI ID: MGI:5523890
• Synonyms: Munc13-1^W464R
• Gene: Unc13a Location: Chr8:72079356-72124418 bp, - strand Genetic Position: Chr8, 34.43 cM, cytoband B3.3
• Alliance: Unc13a^tm4.1Bros page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201701
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Single point mutation
• Mutation details: Exon 11 was replaced with one in which a point mutation (T to C) results in the amino acid substitution of arginine for tryptophan at position 464 (W464R). This mutation abolishes calcium-calmodulin binding. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted downstream of the modified exon 11. (J:201701)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Unc13a Mutation: 74 strains or lines available

References

• Original: J:201701 Lipstein N, et al., Dynamic control of synaptic vesicle replenishment and short-term plasticity by Ca(2+)-calmodulin-Munc13-1 signaling. Neuron. 2013 Jul 10;79(1):82-96
• All: 3 reference(s)