Hprt1^{tm1.1(CAG-Smpd1)Jhkh}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm1.1(CAG-Smpd1)Jhkh}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1.1, Johannes Kornhuber
• MGI ID: MGI:5523896
• Synonyms: Smpd1^ox, t-Asm, tgASM
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm1.1(CAG-Smpd1)Jhkh} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199833
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Hprt1^{tm1.1(CAG-Smpd1)Jhkh} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Smpd1 (MGI:98325)

• Mutation details: The targeting construct inserted into this locus contains the cytomegalovirus (CMV) immediate early enhancer/chicken beta-actin fusion promoter (CAG) driving ubiquitous expression of the mouse cDNA. Cre-mediated recombination removed the floxed STOP cassette inserted between the CAG promoter and mouse cDNA. (J:199833, J:274518)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1279 strains or lines available

References

• Original: J:199833 Gulbins E, et al., Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugs. Nat Med. 2013 Jul;19(7):934-8
• All: 9 reference(s)