Asah1^tm1.1Jhkh
Targeted Allele Detail

Summary

• Symbol: Asah1^tm1.1Jhkh
• Name: N-acylsphingosine amidohydrolase 1; targeted mutation 1.1, Johannes Kornhuber
• MGI ID: MGI:5523898
• Gene: Asah1 Location: Chr8:41793234-41827810 bp, - strand Genetic Position: Chr8, 23.89 cM
• Alliance: Asah1^tm1.1Jhkh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199833
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was floxed and an FRT-lanked neomycin resistance cassette was inserted into the locus. Cre-mediated recombination removed exon 1. (J:199833)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Asah1 Mutation: 39 strains or lines available

References

• Original: J:199833 Gulbins E, et al., Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugs. Nat Med. 2013 Jul;19(7):934-8
• All: 3 reference(s)