Tg(SFTPC-EZR/ROS1)AShiba
Transgene Detail

Summary

• Symbol: Tg(SFTPC-EZR/ROS1)AShiba
• Name: transgene insertion A, Tatsuhiro Shibata
• MGI ID: MGI:5523925
• Synonyms: TgA
• Transgene: Tg(SFTPC-EZR/ROS1)AShiba Location: unknown
• Alliance: Tg(SFTPC-EZR/ROS1)AShiba page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(SFTPC-EZR/ROS1)AShiba expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  EZR (7430)

  Ezr	(MGI:98931)

  human

  ROS1 (6098)

  Ros1	(MGI:97999)

• Mutation details: The FLAG-tagged human fusion EZR/ROS1 cDNA (isolated from LCY66 tumor cDNA) is under the control of a type 2 alveolar epithelium-specific human surfactant protein C gene promoter. Line A harbors approximately four copies of the transgene. Two lines were generated, A and B. (J:199415)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:199415 Arai Y, et al., Mouse model for ROS1-rearranged lung cancer. PLoS One. 2013;8(2):e56010
• All: 1 reference(s)