Pla2g6^tm1Zyao
Targeted Allele Detail

Summary

• Symbol: Pla2g6^tm1Zyao
• Name: phospholipase A2, group VI; targeted mutation 1, Zemin Yao
• MGI ID: MGI:5523997
• Synonyms: iPLA2beta
• Gene: Pla2g6 Location: Chr15:79170428-79212590 bp, - strand Genetic Position: Chr15, 37.7 cM
• Alliance: Pla2g6^tm1Zyao page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203038
• Parent Cell Line: iTL1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A targeting vector containing a neomycin cassette was used to disrupt exon 2. Exon 2 includes the translational start codon. RT-PCR analysis of liver mRNA was used to confirm the absence of the gene. (J:203038)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pla2g6 Mutation: 66 strains or lines available

References

• Original: J:203038 Zhang L, et al., Global Inactivation of the Pla2g6 Gene in Mice Does Not Cause Dyslipidemia under Chow or High-fat Diet Conditions. J Cancer Prev. 2013;18(3):235-248
• All: 1 reference(s)