Brsk2^tm2.1Jrs
Targeted Allele Detail

Summary

• Symbol: Brsk2^tm2.1Jrs
• Name: BR serine/threonine kinase 2; targeted mutation 2.1, Joshua R Sanes
• MGI ID: MGI:5524054
• Synonyms: SAD-A^fl
• Gene: Brsk2 Location: Chr7:141503488-141557981 bp, + strand Genetic Position: Chr7, 87.43 cM, cytoband F5
• Alliance: Brsk2^tm2.1Jrs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201695
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neomycin resistance cassette with a 5' loxP site. Flp-mediated recombination removed the neomycin resistance cassette and left exon 1 floxed. (J:201695)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Brsk2 Mutation: 37 strains or lines available

References

• Original: J:201695 Lilley BN, et al., SAD kinases sculpt axonal arbors of sensory neurons through long- and short-term responses to neurotrophin signals. Neuron. 2013 Jul 10;79(1):39-53
• All: 4 reference(s)