Fbxw7^tm2Iaai
Targeted Allele Detail

Summary

• Symbol: Fbxw7^tm2Iaai
• Name: F-box and WD-40 domain protein 7; targeted mutation 2, Iannis Aifantis
• MGI ID: MGI:5524152
• Synonyms: Fbxw7^R468Neo
• Gene: Fbxw7 Location: Chr3:84722575-84886505 bp, + strand Genetic Position: Chr3, 37.7 cM, cytoband E3.3
• Alliance: Fbxw7^tm2Iaai page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:200006
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 11 was replaced with a floxed neomycin resistance cassette and a modified exon 11 in which nucleotide substitutions (CGG to TGC) result in the amino acid substitution of cysteine for arginine at position 468 (R468C). (J:200006)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fbxw7 Mutation: 84 strains or lines available

References

• Original: J:200006 King B, et al., The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability. Cell. 2013 Jun 20;153(7):1552-66
• All: 1 reference(s)