Eef1a1^{tm1(FBXW7*)Iaai}
Targeted Allele Detail

Summary

• Symbol: Eef1a1^{tm1(FBXW7*)Iaai}
• Name: eukaryotic translation elongation factor 1 alpha 1; targeted mutation 1, Iannis Aifantis
• MGI ID: MGI:5524154
• Synonyms: Eef1a1^mutW7
• Gene: Eef1a1 Location: Chr9:78385735-78389006 bp, - strand Genetic Position: Chr9, 43.65 cM, cytoband E1
• Alliance: Eef1a1^{tm1(FBXW7*)Iaai} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:200006
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neomycin resistance cassette and an N-terminally flag tagged human cDNA encoding a mutant form with the R465C substitution were inserted into intron 1. Cre-mediated recombination is required to achieve expression of the cDNA. (J:200006)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eef1a1 Mutation: 60 strains or lines available

References

• Original: J:200006 King B, et al., The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability. Cell. 2013 Jun 20;153(7):1552-66
• All: 2 reference(s)