Tg(TG-BRAF*V600E)3Jaf
Transgene Detail
|
Symbol: |
Tg(TG-BRAF*V600E)3Jaf |
Name: |
transgene insertion 3, James A Fagin |
MGI ID: |
MGI:5524235 |
Synonyms: |
Tg-BRAF3 |
Transgene: |
Tg(TG-BRAF*V600E)3Jaf Location: unknown
|
Alliance: |
Tg(TG-BRAF*V600E)3Jaf page
|
|
|
Transgene Type: |
|
Transgenic (Inserted expressed sequence) |
Mutation: |
|
Insertion
|
|
|
Tg(TG-BRAF*V600E)3Jaf expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
BRAF (673) |
|
Transgene codes for a protein with a valine to glutamic acid mutation. |
|
|
|
Mutation details: The human BRAF cDNA with a thymine-to-adenine transversion at position 1799A leading to a valine-to-glutamate substitution at residue 600 (V600E) and an NH2-terminal myc tag are under the control of the thyroid-specific bovine thyroglobulin promoter. Quantitative RT-PCR and Western blot analysis confirmed mRNA and protein expression in thyroid tissue. This is the lower expressing line.
(J:98550)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
|
Original: |
J:98550 Knauf JA, et al., Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation. Cancer Res. 2005 May 15;65(10):4238-45 |
All: |
2 reference(s) |
|