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Tg(TG-BRAF*V600E)3Jaf
Transgene Detail
Summary
Symbol: Tg(TG-BRAF*V600E)3Jaf
Name: transgene insertion 3, James A Fagin
MGI ID: MGI:5524235
Synonyms: Tg-BRAF3
Transgene: Tg(TG-BRAF*V600E)3Jaf  Location: unknown  
Alliance: Tg(TG-BRAF*V600E)3Jaf page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(TG-BRAF*V600E)3Jaf expresses 1 gene
 
Mutation detailsThe human BRAF cDNA with a thymine-to-adenine transversion at position 1799A leading to a valine-to-glutamate substitution at residue 600 (V600E) and an NH2-terminal myc tag are under the control of the thyroid-specific bovine thyroglobulin promoter. Quantitative RT-PCR and Western blot analysis confirmed mRNA and protein expression in thyroid tissue. This is the lower expressing line. (J:98550)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:98550 Knauf JA, et al., Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation. Cancer Res. 2005 May 15;65(10):4238-45
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory