C1galt1^tm1.1Staka
Targeted Allele Detail

Summary

• Symbol: C1galt1^tm1.1Staka
• Name: core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1; targeted mutation 1.1, Satoru Takahashi
• MGI ID: MGI:5524266
• Synonyms: C1galt1^flox
• Gene: C1galt1 Location: Chr6:7845224-7872042 bp, + strand Genetic Position: Chr6, 3.37 cM, cytoband A1
• Alliance: C1galt1^tm1.1Staka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:202276
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT- and loxP-flanked neomycin resistance cassette was inserted downstream of exon 3. Flp-mediated recombination removed the neomycin resistance cassette. (J:202276)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any C1galt1 Mutation: 26 strains or lines available

References

• Original: J:202276 Kudo T, et al., C1galt1-deficient mice exhibit thrombocytopenia due to abnormal terminal differentiation of megakaryocytes. Blood. 2013 Aug 29;122(9):1649-57
• All: 1 reference(s)