Slc4a11^tm1.1Jrcy
Targeted Allele Detail

Summary

• Symbol: Slc4a11^tm1.1Jrcy
• Name: solute carrier family 4, sodium bicarbonate transporter-like, member 11; targeted mutation 1.1, Joseph R Casey
• MGI ID: MGI:5524270
• Gene: Slc4a11 Location: Chr2:130526033-130539439 bp, - strand Genetic Position: Chr2, 63.24 cM
• Alliance: Slc4a11^tm1.1Jrcy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:202267
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 9 through 13 were floxed. Cre-mediated recombination removed exons 9 through 13. Immunohistochemistry confirmed the absence of protein expression in the cornea. (J:202267)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc4a11 Mutation: 52 strains or lines available

References

• Original: J:202267 Vilas GL, et al., Transmembrane water-flux through SLC4A11: a route defective in genetic corneal diseases. Hum Mol Genet. 2013 Nov 15;22(22):4579-90
• All: 7 reference(s)