Tg(TG-rtTA)30Jaf
Transgene Detail

Summary

• Symbol: Tg(TG-rtTA)30Jaf
• Name: transgene insertion 30, James A Fagin
• MGI ID: MGI:5524274
• Synonyms: TG-rtTA
• Transgene: Tg(TG-rtTA)30Jaf Location: unknown
• Alliance: Tg(TG-rtTA)30Jaf page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Transactivator)
• Mutation: Insertion
• Mutation details: The reverse tetracycline transactivator rtTA2s-M2 cDNA is under the control of the thyroid-specific bovine thyroglobulin promoter. qRT-PCR confirmed rtTA expression in thyroid tissue. (J:184420)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:184420 Chakravarty D, et al., Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation. J Clin Invest. 2011 Dec;121(12):4700-11
• All: 4 reference(s)