Gt(ROSA)26Sor^{tm1(TMPRSS2/ERG)Key}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(TMPRSS2/ERG)Key}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Charles L Sawyers
• MGI ID: MGI:5524275
• Synonyms: Rosa26^ERG
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(TMPRSS2/ERG)Key} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:200002
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(TMPRSS2/ERG)Key} expresses 2 genes
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ERG (2078)

  Erg	(MGI:95415)

  human

  TMPRSS2 (7113)

  Tmprss2

  (MGI:1354381)

• Mutation details: The targeting construct introduced into the locus a splice acceptor sequence, floxed neomycin resistance STOP (4x polyadenylation sequence) cassette, fusion of human TMPRSS2 (exon 1) and ERG (exon 4), IRES, nuclear localized EGFP and polyadenylation sequence. (J:200002)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 992 strains or lines available

References

• Original: J:200002 Chen Y, et al., ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss. Nat Med. 2013 Aug;19(8):1023-9
• All: 8 reference(s)