Tg(tetO-BRAF*V600E)26Jaf
Transgene Detail

Summary

• Symbol: Tg(tetO-BRAF*V600E)26Jaf
• Name: transgene insertion 26, James A Fagin
• MGI ID: MGI:5524276
• Synonyms: tetO-BRAF^V600E
• Transgene: Tg(tetO-BRAF*V600E)26Jaf Location: unknown
• Alliance: Tg(tetO-BRAF*V600E)26Jaf page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Constitutively active, Epitope tag, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: The multimerized tetO-minimal CMV promoter drives the inducible expression of myc-tagged human BRAF with a valine-to-glutamate substitution at residue 600 (V600E). (J:184420)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:184420 Chakravarty D, et al., Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation. J Clin Invest. 2011 Dec;121(12):4700-11
• All: 4 reference(s)