Bcr^{tm1(BCR/ABL)Tsr}
Targeted Allele Detail

Summary

• Symbol: Bcr^{tm1(BCR/ABL)Tsr}
• Name: BCR activator of RhoGEF and GTPase; targeted mutation 1, Theodora S Ross
• MGI ID: MGI:5524984
• Synonyms: Bcr^LSL-B/A, Bcr^LSL-BCR/ABL
• Gene: Bcr Location: Chr10:74896424-75020753 bp, + strand Genetic Position: Chr10, 38.49 cM
• Alliance: Bcr^{tm1(BCR/ABL)Tsr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203111
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: Human BCR/ABL p210-IRES-EGFP cDNA and an Frt-flanked neomycin cassette were introduced to exon 1 of the mouse Bcr gene downstream of a loxP-flanked Stop cassette via homologous recombination. (J:203111)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bcr Mutation: 51 strains or lines available

References

• Original: J:203111 Foley SB, et al., Expression of BCR/ABL p210 from a knockin allele enhances bone marrow engraftment without inducing neoplasia. Cell Rep. 2013 Oct 17;5(1):51-60
• All: 3 reference(s)