Tg(Prnp-MAPT*P301L)#Ruvi
Transgene Detail

Summary

• Symbol: Tg(Prnp-MAPT*P301L)#Ruvi
• Name: transgene insertion, Ruben Vidal
• MGI ID: MGI:5525087
• Synonyms: Tg-Tau
• Transgene: Tg(Prnp-MAPT*P301L)#Ruvi Location: unknown Genetic Position: ChrX, Syntenic
• Alliance: Tg(Prnp-MAPT*P301L)#Ruvi page

Transgene origin

• Strain of Origin: C3HeB/FeJ

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-MAPT*P301L)#Ruvi expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MAPT (4137)

  Mapt	(MGI:97180)

• Mutation details: The murine Prnp promoter drives the expression of the smallest 4-repeat human isoform of MAPT (Tau) with the frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) P301S mutation. Southern blot analysis indicates one integration site and incorporation of approximately 60-70 copies of the transgene. 8 founders were established, however the pound symbol (#) is used when line is not specified and/or lines are pooled. (J:197198)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:197198 Garringer HJ, et al., Increased tau phosphorylation and tau truncation, and decreased synaptophysin levels in mutant BRI2/tau transgenic mice. PLoS One. 2013;8(2):e56426
• All: 1 reference(s)