Hif1a^tm3.1Rsjo
Targeted Allele Detail

Summary

• Symbol: Hif1a^tm3.1Rsjo
• Name: hypoxia inducible factor 1, alpha subunit; targeted mutation 3.1, Randall S Johnson
• MGI ID: MGI:5525150
• Gene: Hif1a Location: Chr12:73948186-73994304 bp, + strand Genetic Position: Chr12, 31.99 cM
• Alliance: Hif1a^tm3.1Rsjo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:202737
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination using mice carrying Gt(ROSA)26Sor^{tm16(cre)Arte} removed exon 2 from Hif1a^tm3Rsjo mice (J:202737)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hif1a Mutation: 50 strains or lines available

References

• Original: J:202737 Arsenault PR, et al., A Knock-in Mouse Model of Human PHD2 Gene-associated Erythrocytosis Establishes a Haploinsufficiency Mechanism. J Biol Chem. 2013 Nov 22;288(47):33571-84
• All: 2 reference(s)