Mrap2^tm1.2Maj
Targeted Allele Detail

Summary

• Symbol: Mrap2^tm1.2Maj
• Name: melanocortin 2 receptor accessory protein 2; targeted mutation 1.2, Joseph A Majzoub
• MGI ID: MGI:5526064
• Synonyms: Mrap2^flox
• Gene: Mrap2 Location: Chr9:87026359-87066098 bp, + strand Genetic Position: Chr9, 46.76 cM
• Alliance: Mrap2^tm1.2Maj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199365
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin cassette in intron 3, along with loxP sites in intron 2 and 3' of Frt site were incorporated into the genome. Flpe-mediated excision removed the neomycin cassette, leaving exon 3 floxed. (J:199365)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mrap2 Mutation: 17 strains or lines available

References

• Original: J:199365 Asai M, et al., Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity. Science. 2013 Jul 19;341(6143):275-8
• All: 1 reference(s)