Tg(ACTB-KRAS*G12V,-luc)#Lche
Transgene Detail

Summary

• Symbol: Tg(ACTB-KRAS*G12V,-luc)#Lche
• Name: transgene insertion, Lukas C Heukamp
• MGI ID: MGI:5526090
• Synonyms: RASLO
• Transgene: Tg(ACTB-KRAS*G12V,-luc)#Lche Location: unknown
• Alliance: Tg(ACTB-KRAS*G12V,-luc)#Lche page

Transgene origin

• Strain of Origin: (C57BL/6 x FVB/N)F1

Transgene description

• Transgene Type: Transgenic (Conditional ready, Constitutively active, Inserted expressed sequence)
• Mutation: Insertion
• Tg(ACTB-KRAS*G12V,-luc)#Lche expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Kras

• Mutation details: A transgene consisting of a 1.8 kb chicken beta-actin promoter, a floxed STOP codon, a mutated KRAS^VAL12, a polyoma virus internal ribosomal re-entry site, and a fusion molecule consisting of chicken ovalbumin, an S-tag and a luciferase molecule. Expression of the constitutively active oncogenic KRAS^V12 is dependent on Cre-mediated deletion of the STOP codon. The pound symbol (#) is used because a line number was not specified. (J:199528)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:199528 Konig K, et al., Loss of the keratin cytoskeleton is not sufficient to induce epithelial mesenchymal transition in a novel KRAS driven sporadic lung cancer mouse model. PLoS One. 2013;8(3):e57996
• All: 2 reference(s)