Jak1^M1Mhda
Chemically induced Allele Detail

Summary

• Symbol: Jak1^M1Mhda
• Name: Janus kinase 1; mutation 1, Martin Hrabe de Angelis
• MGI ID: MGI:5526094
• Synonyms: BAP004, Jak1^BAP004, Jak1^S645P, Jak1^S645PMhda
• Gene: Jak1 Location: Chr4:101009564-101122479 bp, - strand Genetic Position: Chr4, 46.19 cM
• Alliance: Jak1^M1Mhda page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU) (Constitutively active)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a point mutation at the conserved serine at position 645 of the pseudokinase domain (p.Ser645Pro) corresponding to a somatic human mutation (p.Ser646Phe) inducing constitutive activation of the Janus Kinase/STAT pathway. (J:68708, J:199153)
• Inheritance: Dominant

Disease models

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Jak1 Mutation: 50 strains or lines available

References

• Original: J:68708 Hrabe de Angelis MH, et al., Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nat Genet. 2000 Aug;25(4):444-7
• All: 6 reference(s)