Usp7^tm2.1Wgu
Targeted Allele Detail

Summary

• Symbol: Usp7^tm2.1Wgu
• Name: ubiquitin specific peptidase 7; targeted mutation 2.1, Wei Gu
• MGI ID: MGI:5526105
• Synonyms: hausp^deltaEx6
• Gene: Usp7 Location: Chr16:8506586-8574931 bp, - strand Genetic Position: Chr16, 4.28 cM
• Alliance: Usp7^tm2.1Wgu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203102
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 6. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 6. Cre-mediated recombination removed exon 6 and the neomycin resistance cassette. (J:203102)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Usp7 Mutation: 63 strains or lines available

References

• Original: J:203102 Kon N, et al., Roles of HAUSP-mediated p53 regulation in central nervous system development. Cell Death Differ. 2011 Aug;18(8):1366-75
• All: 1 reference(s)