Gabrd^tm1.1Jmag
Targeted Allele Detail

Summary

• Symbol: Gabrd^tm1.1Jmag
• Name: gamma-aminobutyric acid (GABA) A receptor, subunit delta; targeted mutation 1.1, Jamie Maguire
• MGI ID: MGI:5526859
• Gene: Gabrd Location: Chr4:155469437-155482528 bp, - strand Genetic Position: Chr4, 86.17 cM
• Alliance: Gabrd^tm1.1Jmag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203336
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector containing a FRT site flanked PGK-NEO cassette and a loxP site was inserted into exon 6 of the targeted gene, and another loxP site was inserted upstream of exon 2. Flp-mediated recombination removed the neomycin resistance cassette and left exons 2 through 5 and a portion of exon 6 floxed. (J:203336)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gabrd Mutation: 31 strains or lines available

References

• Original: J:203336 Lee V, et al., Impact of inhibitory constraint of interneurons on neuronal excitability. J Neurophysiol. 2013 Dec;110(11):2520-35
• All: 6 reference(s)